Skip to main content
. 2018 Aug 23;26(7):1103–1111. doi: 10.3727/096504018X15164123839400

Figure 3.

Figure 3

E2F5 is identified as target of let-7c. (A) The level of E2F5 in four glioma cell lines and a normal astrocyte cell line was detected. (B) Bioinformatics analysis helped us obtain the binding sites between let-7c and E2F5. (C). Luciferase reporter assays further confirmed the regulating relationship between let-7c and E2F5 after wild-type (WT) or mutant (Mut) E2F5 transfection. (D) The expression of E2F5 in response to the levels of let-7c. Error bars represent the mean ± SD of at least three independent experiments. *p < 0.05, **p < 0.01 versus control group (astrocytes or NC).