The oncogenic function of CRNDE in radioresistant LAD cells is in a p21-dependent manner. (A) MTT assay was performed to assess the sensitivity of LAD cells cotransfected with siRNA, si-CRNDE, and si-p21 to radiation. (B) Colony formation assays were performed to measure the proliferation ability of LAD cells cotransfected with siRNA, si-CRNDE, or si-p21. Flow cytometry analysis was performed to assess the cell cycle percentages (C) and apoptosis rate (D) of LAD cells cotransfected with siRNA, si-CRNDE, or si-p21. All data are represented as the mean ± SD from three independent experiments. The p value represents the comparison between groups (*p < 0.05, **p < 0.01).