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. 2018 Aug 23;26(7):1023–1029. doi: 10.3727/096504018X15151515028670

Figure 3.

Figure 3

GATA-binding factor 6 (GATA6) was a direct target of miR-143 in GC. (A) GATA6 was predicted as a potential target of miR-143 by TargetScan online software. (B) The relative luciferase activity in BGC-823 or SGC-7901 cells was detected after the wild-type (WT) or mutant (Mut) GATA6 3′-untranslated region (3′-UTR) genes were cotransfected with miR-NC or miR-143 mimic. (C) RT-qPCR. (D) Western blot was used to analyze GATA6 expression in SGC-7901 and BGC-823 cell lines after miR-143 mimic or miR-NC transfection. (E) The expression of GATA6 was inversely correlated with the expression of miR-143 in GC. *p < 0.05, **p < 0.01.