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. 2018 May 7;26(4):637–644. doi: 10.3727/096504017X15112639918174

Figure 1.

Figure 1

MicroRNA 767-3p (miR-767-3p) was downregulated in lung adenocarcinoma and is negatively correlated with claudin 18 (CLDN18) expression. (A) miRNA meta-analysis in YM500v2 (http://ngs.ym.edu.tw/ym500v2/index.php) was performed to detect the differential expression of miRNAs in lung adenocarcinoma compared to the control normal tissue. Group 1: normal tissue, group 2: lung adenocarcinoma. (B) The levels of miR-767-3p in 39 cases of lung adenocarcinoma and 20 cases of normal tissues were detected by qualitative reverse transcriptase polymerase chain reaction (qRT-PCR). (C) qRT-PCR assay was performed to detect the levels of CLDN18 in lung adenocarcinoma tissues and normal tissues. (D) Immunohistochemistry (IHC) staining was used to measure the expression of CLDN18 in lung adenocarcinoma and normal tissues. Scale bar: 200 μM. Data are expressed as mean ± SD. **p < 0.01, compared with normal tissues. (E) The level of miR-767-3p was negatively correlated with CLDN18 in lung adenocarcinoma. (F) The RNA levels of miR-767-3p and CLDN18 were measured in a panel of lung adenocarcinoma cell lines. Data are expressed as mean ± SD. **p < 0.01, compared to BEAS-2B cells.