Table 3.

Adverse events

	Grade 1–2	Grade 3	Grade 4	Grade 5
Neutropenia	2 (3%)	5 (7%)	41 (55%)	0
Anaemia	8 (11%)	22 (29%)	4 (5%)	0
Thrombocytopenia	2 (3%)	1 (1%)	44 (59%)	0
Infections	17 (23%)	14 (19%)	8 (11%)	4 (5%)
Hepatotoxicity	8 (11%)	13 (17%)	0	0
Nephrotoxicity	7 (9%)	0	1 (1%)	0
Mucositis	8 (11%)	3 (4%)	1 (1%)	0
Nausea, vomiting, or diarrhoea	17 (23%)	3 (4%)	0	0
Central and peripheral neurotoxicity	10 (13%)	3 (4%)	0	0
Cardiotoxicity	2 (3%)	1 (1%)	0	0
Vascular events*	2 (3%)	1 (1%)	1 (1%)	0

Grade 1 or 2 adverse events are reported if occurring in at least 10% of patients in the treated population (n=75). In patients with multiple concomitant toxicities, each side-effect was considered and reported in the table separately.

^*Deep vein thrombosis, pulmonary thromboembolism, or stroke.