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. 2018 Jul 5;26(6):827–835. doi: 10.3727/096504017X14934840662335

Figure 5.

Figure 5

miR-21 in CAFs regulates drug resistance to gemcitabine in a PDAC mouse model. A PDAC mouse model was established with Panc02 cell lines and CAFs with various levels of miR-21 and accepted gemcitabine treatment after 1 week of implantation. (A) Increase in tumor volume over time after implantation. The mice with CAFs having the miR-21 mimic grew the fastest, while the mice with CAFs having the miR-21 inhibitor grew the slowest. (B) Survival curves of the mice with CAFS having different levels of miR-21. Consistent with tumor volume growth, the mice with high miR-21 expression CAFs had the shortest survival time, and the mice with low miR-21 expression CAFs had the longest survival time.