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. 2018 Jul 5;26(6):977–985. doi: 10.3727/096504017X15037506066252

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Copyright © 2018 Cognizant, LLC.

This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.

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Suppression of miR-34a-5p promoted cell viability, migration, and invasion by increasing the expression of Bcl-2. (A) Overexpression and suppression of Bcl-2 in HeLa cells after transfection with pEX-Bcl-2 or short hairpin (sh)-Bcl-2, respectively. (B) miR-34a-5p inhibitor-induced HeLa cell viability enhancement was reversed by suppression of Bcl-2. (C) miR-34a-5p inhibitor-induced HeLa cell migration enhancement was reversed by suppression of Bcl-2. (D) miR-34a-5p inhibitor-induced HeLa cell invasion enhancement was reversed by suppression of Bcl-2. (E) Silencing of Bcl-2 increased the apoptosis of HeLa cells. (F) Silencing of Bcl-2 upregulated the expression levels of Bax, cleaved caspase 3, and cleaved caspase 9 in HeLa cells. GAPDH was used as the loading control. *p < 0.05; **p < 0.01; ***p < 0.001.