Overexpression and suppression of Bcl-2 and their effects on cell viability, migration, invasion, and apoptosis in HeLa cells. (A) Overexpression of Bcl-2 promoted cell viability, while suppression of Bcl-2 inhibited cell viability. (B) Overexpression of Bcl-2 promoted cell migration, while suppression of Bcl-2 inhibited cell migration. (C) Overexpression of Bcl-2 promoted cell invasion, while suppression of Bcl-2 inhibited cell invasion. (D) Suppression of Bcl-2 promoted cell apoptosis. (E) Suppression of Bcl-2 enhanced the expressions of Bax, cleaved caspase 3, and cleaved-caspase 9 in HeLa cells. GAPDH was used as the loading control. *p < 0.05; **p < 0.01; ****p < 0.0001.