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. 2018 May 7;26(4):547–556. doi: 10.3727/096504017X15016337254605

Figure 1.

Figure 1

Expression of miR-449a level in lung cancerous tissues and cells. (A) Reverse transcription polymerase chain reaction (RT-PCR) evaluation of miR-449a expression in non-small cell lung cancer (NSCLC) tissue samples and matched noncancerous normal tissue samples (n = 22). (B) Expression of miR-449a in NSCLC tissue samples at different stages (I: n = 6, II: n = 11, III: n = 5). (C) Levels of serum miR-449a in ionizing radiation (IR)-sensitive (n = 15) and IR-resistant (n = 12) patients. (D) Expression of miR-449a in normal human bronchial epithelial (HBE) cells and lung cancer cells. **p < 0.01, compared to HBE. (E, F) Change of miR-449a expression at 48 h of culture in response to increasing doses of IR at 2, 4, 8, and 12 Gy in A549 and H1299 cells. **p < 0.01, *p < 0.05, compared to 0 Gy. (G, H) Change in miR-449a expression within 48 h in A549 and H1299 cells after IR (8 Gy) treatment. **p < 0.01, compared to 0 Gy. All experiments were repeated at least three times.