Skip to main content
. 2018 May 7;26(4):547–556. doi: 10.3727/096504017X15016337254605

Figure 5.

Figure 5

LDHA inhibition enhances IR sensitivity in lung cancer cells. (A) LDHA siRNA and its control siRNA were transfected into A549 and H1299 cells, and the expression of LDHA was determined 48 h after the transfections using Western blot. (B) Lactate production after LDHA inhibition in lung cancer cells was examined 48 h after transfection. **p < 0.01, compared to control. (C) Cell apoptosis in A549 and H1299 cells after LDHA inhibition with or without IR exposure at 48 h. (D) DNA damages by IR exposure in lung cancer cells transfected with LDHA siRNA or control siRNA. **p < 0.01, compared to siR-Ctrl; ##p < 0.01, compared to IR-siR-Ctrl. All experiments were repeated at least three times.