Table 1.

Ibuprofen and chickenpox

Year	1st author (Ref)	Children (N)	Disorder	Treatment	Adverse events
1997	Choo [26]	7865	Chickenpox	Ibuprofen	SSTI
1999	Zerr [23]	48	Chickenpox	Ibuprofen	Necrotizing fascitis
2001	Lesko [27]	224	Chickenpox	Ibuprofen +/−	GAS infections and
				paracetamol	soft tissues necrosis
2008	Mikaeloff [28]	140,111	Chickenpox	Ibuprofen	Cellulitis, abscess,
				(or other NSAIDs)	fasciitis and necrosis
2008	Souyry [29]	266	Chickenpox	Ibuprofen	Serious necrotising
			and other	(or other NSAIDs)	soft-tissue infections
			viral infections
2008	Dubos [30]	159	Chickenpox	Ibuprofen	Secondary bacterial
					skin complications

GAS Group A streptococci, N Number of enrolled children, NSAIDs Non-steroidal anti-inflammatory drugs, Ref Reference number, SSTI Skin and soft tissue infection