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. 2018 May 7;26(4):519–528. doi: 10.3727/096504017X15000757094686

Figure 4.

Figure 4

Downregulation of PDCD10 is involved in miR-103-induced inhibition of proliferation and migration of A549 cell line. A549 cells were cotransfected with NC or the miR-103 mimic and pcDNA or pcDNA PDCD10. (A) Cell proliferation was determined by the CCK-8 assay kit. (B, C) The apoptosis distribution was detected by flow cytometry (B) and expressed as fold increase versus control (C). mRNA expression of Bax (D) and Bcl-2 (E) was determined by qRT-PCR and expressed as folds of control. Transwell assays (F) and wound healing assays (G) were performed in A549 cells. mRNA expression of Bax (H) and Bcl-2 (I) was determined by qRT-PCR and expressed as fold of control. n = 3–4 independent experiments. Error bars represent the mean ± SEM. *p < 0.05, compared with control. #p < 0.05, compared with miR-103.