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. 2020 Dec 22;11:610205. doi: 10.3389/fphar.2020.610205

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Copyright © 2020 Chang, Wang, Niu, Song and Zou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alkannin and olaparib together suppresses growth of tumor xenografts in vivo. (A) Photograph of tumor mass dissected out at the time of study termination. (B) Tumor volume-time curve. Tumor volume was measured every 3 days and calculated according to formula V = 1/2 length × width². (C) Tumor weight measured at the end of the study. (D) Body weight-time curve. Body weight was measured every 2 days. n.s. not significant, ***:p < 0.001. (E) Representative images of DNA damage (γH2AX) and apoptosis (TUNEL) in tumor tissues (scale bars: 20 μm). (F) Model for synergistic cytotoxicity of alkannin and PARP inhibitors in cancer cells.