Table 6.
TG parameter comparison between men and women with and without the use of oral contraceptives
| Men (N = 58) | Women –OCs (N = 44) | Women + OCs (N = 13‐15) | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Median | IQR | Median | IQR | Median | IQR | M/W– | M/W+ | W–/W+ | |
| STG‐BleedScreen | |||||||||
| Lag time, min | 3.1 | 2.8‐3.6 | 2.7 | 2.5‐3.2 | 2.5 | 2.1‐2.6 | .0082 | <.0001 | NS |
| Peak height, nM | 162 | 140‐194 | 164 | 120‐194 | 271 | 223‐312 | NS | <.0001 | <.0001 |
| Time to peak, min | 6.8 | 6.1‐7.6 | 6.3 | 5.8‐7.2 | 5.2 | 4.3‐5.9 | NS | <.0001 | .0102 |
| ETP, Nm/min | 1092 | 937‐1229 | 1070 | 906‐1312 | 1374 | 1147‐1543 | NS | .0030 | .0037 |
| Velocity index, nM/min | 58.4 | 42.1‐74.8 | 56.9 | 43.3‐77.3 | 130 | 89.4‐157 | NS | <.0001 | <.0001 |
| Start tail, min | 19.8 | 17.8‐21.9 | 20.1 | 16.7‐22.7 | 16.0 | 14.6‐18.9 | NS | .0062 | .0057 |
| STG‐DrugScreen | |||||||||
| Lag time, min | 1.4 | 1.3‐1.6 | 1.3 | 1.2‐1.4 | 1.2 | 1.1‐1.3 | .0181 | .0002 | NS |
| Peak height, nM | 334 | 296‐378 | 338 | 301‐402 | 483 | 410‐539 | NS | <.0001 | .0006 |
| Time to peak, min | 3.1 | 2.6‐3.4 | 2.7 | 2.4‐3.0 | 2.4 | 2.1‐2.5 | .0246 | <.0001 | NS |
| ETP, nM/min | 1185 | 1081‐1402 | 1224 | 1059‐1413 | 1409 | 1183‐1851 | NS | .0492 | NS |
| Velocity index, nM/min | 299.0 | 206‐367 | 338.0 | 277‐425 | 585 | 418‐782 | NS | <.0001 | .0004 |
| Start tail, min | 11.4 | 10.6‐12.8 | 11.3 | 10.2‐12.3 | 10.9 | 10.1‐11.7 | NS | NS | NS |
| STG‐ThromboScreen –TM | |||||||||
| Lag time, min | 2.5 | 2.2‐2.8 | 2.2 | 2.0‐2.5 | 2.0 | 1.8‐2.2 | .0390 | .0002 | NS |
| Peak height, nM | 190 | 169‐219 | 194 | 161 ‐229 | 280 | 240‐376 | NS | <.0001 | <.0001 |
| Time to peak, min | 5.7 | 5.1‐6.4 | 5.1 | 4.7‐6.1 | 4.4 | 3.6‐4.7 | NS | <.0001 | .0097 |
| ETP, nM/min | 1130 | 974‐1362 | 1100 | 969‐1332 | 1414 | 1154‐1774 | NS | .0109 | .0098 |
| Velocity index, nM/min | 71.9 | 59.6‐95.2 | 83.7 | 63.1‐112 | 191 | 118‐259 | NS | <.0001 | <.0001 |
| Start tail, min | 17.6 | 14.9‐19.3 | 16.8 | 15.2‐19 | 14.6 | 13.6‐15.4 | NS | .0045 | .0153 |
| STG‐ThromboScreen + TM | |||||||||
| Lag time, min | 2.5 | 2.2‐2.8 | 2.1 | 2.0‐2.5 | 2.0 | 1.8‐2.2 | .0435 | .0004 | NS |
| Peak height, nM | 114 | 83‐137 | 133 | 91‐180 | 309 | 197‐339 | NS | <.0001 | <.0001 |
| Time to peak, min | 4.8 | 4.3‐5.1 | 4.4 | 4.1‐4.8 | 3.9 | 3.4‐4.2 | NS | .0003 | NS |
| ETP (nM/min) | 499 | 373‐643 | 594 | 425‐799 | 1124 | 900‐1397 | NS | <.0001 | .0001 |
| Velocity index, nM/min | 64.7 | 45.7‐78.9 | 78.9 | 50.5‐118 | 217 | 123‐295 | NS | <.0001 | <.0001 |
| Start tail, min | 13.3 | 12.6‐14.8 | 13.5 | 12.8‐14.1 | 13.2 | 12.1‐14.3 | NS | NS | NS |
| ETP inhibition, % | 57 | 43‐66 | 45 | 35‐63 | 25.4 | 19‐31 | NS | <.0001 | .0005 |
Data are shown as median values with interquartile ranges (IQRs).
Abbreviations: ETP, endogenous thrombin potential; M, men; NS, not significant; OCs, oral contraceptives; TM, thrombomodulin; W–, women without OCs; W+, women with OCs.