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. 2021 Jan 28;13:13. doi: 10.1186/s13073-021-00828-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Comparison of MI Risk Scores with and without non-fixed risk factors. a Scatterplots of the full model (18-feature established-at-birth + non-fixed + PRS score) against the non-modifiable risk model (9-feature established-at-birth + PRS score). Individuals below the regression line (red, Group A in the middle panel) have comparatively lower predicted risk later in life compared to their predicted risk at birth, whereas those above the regression line (blue, Group B) have higher predicted risk of MI later in life; both groups represent the 2% extremes. The right -hand panel highlights individuals with relatively low risk according to both models (Group C, orange) or relatively high risk according to both models (cyan, Group D). b, c Standardized distributions of indicated non-fixed risk factors for the selected subsets of individuals, implying that high risk individuals are older and more overweight