Table 2.
Percentile | PRS only (4-feature model) | Established-at-birth only (5-feature model) | Established-at-birth plus PRS (9-feature model) | Established-at-birth plus non-fixed (14-feature model) | Established-at-birth plus non-fixed plus PRS (18-feature model) | |
---|---|---|---|---|---|---|
IHD | Top percentile | 21.95% ± 1.39 | 13.52% ± 1.10 | 29.98% ± 1.65 | 55.71% ± 1.83 | 60.25% ± 1.37 |
IHD | Middle percentile | 8.76% ± 0.80 | 5.48% ± 0.63 | 7.69% ± 0.89 | 5.34% ± 0.70 | 4.50% ± 0.69 |
IHD | Lowest percentile | 3.45% ± 0.47 | 4.56% ± 0.71 | 2.79% ± 0.63 | 0.48% ± 0.18 | 0.41% ± 0.12 |
MI | Top percentile | 11.38% ± 1.05 | 6.60% ± 0.72 | 16.78% ± 1.10 | 30.95% ± 1.63 | 35.90% ± 1.66 |
MI | Middle percentile | 3.19% ± 0.35 | 1.72% ± 0.30 | 1.95% ± 0.42 | 1.54% ± 0.46 | 1.11% ± 0.20 |
MI | Lowest percentile | 0.68% ± 0.31 | 1.98% ± 0.34 | 0.59% ± 0.22 | 0.09% ± 0.09 | 0.14% ± 0.14 |
Early MI | Top percentile | 0.88% ± 0.32 | 0.27% ± 0.28 | 1.34% ± 0.42 | 4.15% ± 0.52 | 4.67% ± 0.83 |
Early MI | Middle percentile | 0.07% ± 0.08 | 0.02% ± 0.05 | 0.07% ± 0.11 | 0.02% ± 0.05% | 0.00% ± 0.05 |
Early MI | Lowest percentile | 0.00% ± 0.00 | 0.02% ± 0.05 | 0.00% ± 0.00 | 0.00% ± 0.00 | 0.00% ± 0.00 |
Entries are observed prevalence of IHD, MI, or early MI, plus or minus 95% CI from 10-fold cross-validation in each indicated model for the top, middle, and bottom 1% of polygenic risk