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. 2021 Jan 29;22:53. doi: 10.1186/s13059-021-02269-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Overview of the web interface. My Personal Mutanome has an all-in-one interface that allows users to search (a), view results (b, c), and visualize nodetic/edgetic mutations (Figs. 4 and 5) in the same web page, improving the smoothness in navigating through the database and removing the needs for switching between browser tabs. Users can use both UniProt ID and gene symbol to search for a protein or a specific PPI (a), which loads the basic information page (b). These pages provide an overview of the data that are available for the proteins, PPIs, mutations, and functional site in My Personal Mutanome. (c) Additional information such as all the mapped mutations for a specific PPI can be loaded on user request. Survival and drug responses are found by loading the “Edgetic” and the “Pharmacogenomics” information on the PPI and functional site pages. By clicking the buttons, users can browse through all the related information progressively