Fig. 7.

High TRAM2 expression is associated with poor cancer patient survival. a The TCGA Pan-Cancer cohort was used to correlate the expression of TRAM2 and YAP gene signature score [47] with survival probability of cancer patients. The heatmap summarizes the results of Cox regression analysis using either TRAM2 expression (log2(TPM)) or YAP gene signature score. b Kaplan-Meier plots of TCGA studies with significant survival correlation with both TRAM2 expression and YAP gene signature score. Patients were classified as high (larger or equal than the median; red line) or low (lower than the median; green line) for TRAM2 expression (log2(TPM)) and YAP gene signature score. Wald pval, p value of Cox regression calculated in a; n_high, number of patients in category “high”; n_low, number of patients in category “low.” Censors were labeled with a black cross. c Boxplots showing TRAM2 expression (log2(TPM)) in patients classified as high (larger or equal than the median; red dots) or low (lower than the median; green dots) YAP gene signature score in TCGA studies with significant survival correlation with YAP gene signature score in a. d A model for YAP-mediated enhancers network uncovered in this manuscript