Table 1.
Clinical characteristics of trials included in the review
| Author | Type of study | Location(s) | Subjects with diabetes | DPP4i users | Age | % Male | HbA1c | % Hypertension | % CVD | % CKD |
|---|---|---|---|---|---|---|---|---|---|---|
| Solerte | Multicenter, case control study | Northern Italy | 338 | 169 | 69 | 70 | 7.5 | 70 | 39 | 24 |
| Mirani | Single center, case series | Milan (Italy) | 90 | 11 | 71 | 72 | NA | 77 | 39 | 19 |
| Rhee | Healthcare insurance database | Korea | 832 | 263 | 62 | 54 | NA | 68 | 27 | 19 |
| Yan | Multicenter, case control study | China | 57 | 6 | NA | NA | NA | NA | NA | NA |
| Kim | Multicenter, observational study | South Korea | 235 | 85 | 68 | 45 | 7.7 | 63 | 22 | 8 |
| Chen | Single center, observational | Wuhan (China) | 100 | 20 | 66 | NA | 7.9 | 33 | 21 | 12 |
| Silverii | Multicenter, observational study | Sicily (Italy) | 159 | 13 | 73 | 54 | NA | NA | NA | NA |
| Fadini | Single center, case series | North-East Italy | 85 | 9 | 70 | 65 | 7.6 | 69 | 27 | 15 |
| Cariou | Multicenter, observational study | France | 1317 | 285 | 70 | 65 | 8.1 | 77 | 41 | NA |
| Pérez-Belmonte | Multicenter, observational study (with PSM) | Spain | 2666 (210 matched) | 105 | 75 | 62 | NA | 76 | 23 | 13 |
| Dalan | Single center observartional study | Singapore | 76 | 27 | NA | NA | NA | NA | NA | NA |
| Nafakhi | Single center observartional study | Iraq | 67 | 14 | 60 | 43 | NA | 66 | 15 | NA |
| Overall | – | – | 6022 | 1007 | 68 | 61 | 7.6 | 73 | 29 | 15 |
CVD cardiovascular disease; CKD chronic kidney disease, NA not available