TABLE 2.
Candidate predictors available in the development dataset.
| Group | Type of predictor | Candidate predictor | Data collection | Data type | Measurement unit |
|---|---|---|---|---|---|
| A | Sociodemographic and lifestyle-related | Intervention status | Registration form | Cat | Intervention, control |
| Age | Registration form | Cont | Years | ||
| Sex | Registration form | Cat | Male, female | ||
| Living situation | Patient interview | Cat | Home, institutionalized | ||
| Educational | CRF | Cat | Low, medium, high | ||
| Smoking | Patient interview | Cat | Smoker, ex-smoker, non-smoker | ||
| B | Morbidity-related | Hypertension | Patient interview | Bin | No, yes |
| Diabetes mellitus | Patient interview | Bin | No, yes | ||
| Coronary heart disease | Patient interview | Bin | No, yes | ||
| Osteoarthritis | Patient interview | Bin | No, yes | ||
| COPD/asthma | Patient interview | Bin | No, yes | ||
| Vision problems | Patient interview | Bin | No, yes | ||
| Hearing problems | Patient interview | Bin | No, yes | ||
| Cancer | Patient interview | Bin | No, yes | ||
| Heart failure | Patient interview | Bin | No, yes | ||
| Cerebrovascular disease | Patient interview | Bin | No, yes | ||
| Osteoporosis | Patient interview | Bin | No, yes | ||
| Depression | Patient interview | Bin | No, yes | ||
| Rheumatoid/seropositive arthritis | Patient interview | Bin | No, yes | ||
| Atherosclerosis/peripheral vascular disease | Patient interview | Bin | No, yes | ||
| Parkinsonism | Patient interview | Bin | No, yes | ||
| HIV/AIDS | Patient interview | Bin | No, yes | ||
| Lipid disorder | Patient interview | Bin | No, yes | ||
| Gout | Patient interview | Bin | No, yes | ||
| Thyroid disorders | Patient interview | Bin | No, yes | ||
| Gastric or duodenal ulcer | Patient interview | Bin | No, yes | ||
| Liver disorder | Patient interview | Bin | No, yes | ||
| Urinary disease | Patient interview | Bin | No, yes | ||
| Anemia | Patient interview | Bin | No, yes | ||
| No. of chronic conditions | Patient interview | Cont | No, yes | ||
| C | Health status and well-being related | Pain | Patient interview | Bin | No, yes |
| Quality of life (EuroQol Group 1990) | Patient interview | Cont | Score | ||
| Functional status (Saliba et al., 2001) | Patient interview | Cont | Score | ||
| Cognitive function | Patient interview | Cont | Score | ||
| All-cause hospital admissions | Patient interview | Bin | No, yes | ||
| History of falls | Patient interview | Cat | ≤1 fall, ≥ 2 falls | ||
| D | Medication related | No. of drugs | Patient interview | Cont | Frequency |
| ACh burden (Carnahan et al., 2006; Hilmer et al., 2007b; Rudolph et al., 2008; Klamer et al., 2017; Kiesel et al., 2018) | Calculated using medication data from patient interview | Cont | Weighted index | ||
| E | Symptoms | No. of symptoms | Patient interview | Cont | Frequency |
| Dizziness/vertigo | Patient interview | Bin | No, yes | ||
| Problems urinating | Patient interview | Bin | No, yes | ||
| Stomach pain | Patient interview | Bin | No, yes | ||
| Patient interview | Bin | No, yes | |||
| Drowsiness/fatigue a | Patient interview | Bin | No, yes | ||
| Dry mouth a | Patient interview | Bin | No, yes | ||
| Itching a | Patient interview | Bin | No, yes | ||
| Constipation a | Patient interview | Bin | No, yes |
ACh, anticholinergic; Bin., binary; Cat., categorial; Cont., continuous; COPD, chronic obstructive pulmonary disease; CRF, case report form; HIV/AIDS, human immunodeficiency virus/acquired immune deficiency syndrome; No, number.
a
Symptoms only available in the development dataset (RIME).