Table 3.
Case reports and case series of AIHA in CML (hemolysis parameters and transplantation-related information)
| 1st author | Antibody (IgG, IgM) titers | Reticulocytes, % | LDH, U/L | Total bilirubin, mg/dL | Eiaptoglobin, mg/dL | Transfusion, units | Time from diagnosis till treatment | Time from CML diagnosis till transplantation | Transplantation type |
|---|---|---|---|---|---|---|---|---|---|
| Osgood E. [6] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Vidbaek A. [7] | N/A | 3.6–4.6 | N/A | 1.5 | N/A | N/A | Not clear | N/A | N/A |
| N/A | N/A | N/A | 0.4 | N/A | 2 | Not clear | N/A | N/A | |
| Maldonado Ni. [8] | Cold agglutinin 1:8 | 24 | N/A | 2 (1.5 indirect) | N/A | Unit of 500 mL | Not clear | N/A | N/A |
| Cohen S.M. [9] | N/A | 14 | N/A | N/A | N/A | N/A | Not clear | N/A | N/A |
| Arbaje Y.M. [10] | N/A | 10.6 | 375 | 1.1 (0.9 indirect) | 4 | N/A | Not clear | N/A | N/A |
| Klumpp T.R. [11] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Tamura T. [12] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Sacchi S. [13] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Andriani A. [14] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Chen F.E. [15] | N/A | N/A | N/A | 0.27 | N/A | 1 case: 91 units in 7 mo | N/A | N/A | 2 matched unrelated donor, 3 sibling donor |
| 6.23 | |||||||||
| 4.27 | |||||||||
| 0.2 | |||||||||
| 0.7 | |||||||||
| Stavroyianni N. [16] | N/A | 22.2 | 515 | 3.26 (2.7 indirect) | N/A | N/A | N/A | N/A | N/A |
| Cwynarski K. [17] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | Not clear | Matched |
| Köksal A. [18] | N/A | 4.2 | 2,000 | (5 indirect) | 13 | 5 units of 500 mL | N/A | N/A | N/A |
| Tóthová E. [19] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Steegmann J.L. [20] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Qazilbash M.H. [21] | N/A | N/A | 1051 | 4.7 | N/A | N/A | N/A | 2 yr | Matched unrelated donor |
| Sanz J. [22] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 2 matched unrelated 1 minor ABO mismatched 1 sibling donor |
| Calixto R. [23] | IgG 1:2 | N/A | 791 | 7 | N/A | 6 | Directly | N/A | Matched related donor Minor ABO incompatibility |
| Sanz J. [24] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | Unrelated donors: 2 ABO matched 2 ABO minor mismatch |
| Yang Z. [25] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | Unrelated donor |
| Wang M. [26] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 2 unrelated donors |
| Novaretti M.C. [27] | N/A | 61×109/L (count) 1.5 (index) | 487 | N/A | N/A | N/A | N/A | N/A | N/A |
| Rokicka M. [28] | IgG + 4 | N/A | N/A | N/A | N/A | Not defined | N/A | 3 yr | Partially HLA matched Minor ABO mismatch |
| Lewandowski K. [29] | N/A | 61.3 G/L (count) | 294 | Normal | N/A | N/A | N/A | N/A | N/A |
| Garg S. [30] | N/A | N/A | 408 | N/A | N/A | N/A | N/A | N/A | N/A |
| Cao L. [31] | IgG + 1 | 25 | 6,336 | N/A | N/A | >34 | N/A | N/A | Unrelated HLA matched, major ABO mismatch |
CML, chronic myeloid leukemia; AIHA, autoimmune hemolytic anemia; LDH, lactate dehydrogenase; HLA, human leukocyte antigen.