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. 2021 Jan 15;10:581459. doi: 10.3389/fonc.2020.581459

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Copyright © 2021 Han, Korangath, Nguyen, Diehl, Cho, Teo, Cope, Gessler, Romer and Sukumar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HeyL promotes angiogenesis in transgenic mice. (A) Anti-CD31 IHC analysis of blood vessels in mammary glands of 13 week-old virgin, MMTV-HeyL transgenic mice compared to parental FVB/N mice (n=4 mice/group). (B) Number of blood vessels, vessel length and average area occupied by blood vessels in mammary glands from MMTV-HeyL and parental FVB/N mice, analyzed in (A). (C) Mammary tumors arising spontaneously in MMTV-HeyL/Her2-neu are larger compared to those in MMTV-Her2-neu mice (n=22/group). Measurement was initiated after detection of palpable tumors. (D) Anti-CD31 IHC analysis of blood vessels in mammary tumors in MMTV-HeyL/Her2-neu compared to MMTV-Her2-neu mice from (C), (n=6 mice each group) (E). Number of blood vessels, vessel length and average area occupied by blood vessels in mammary tumors in MMTV-HeyL/Her2-neu mice compared to MMTV-Her2-neu mice from (D) *P < 0.05; **< 0.05.