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. 2021 Jan 15;10:581459. doi: 10.3389/fonc.2020.581459

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Copyright © 2021 Han, Korangath, Nguyen, Diehl, Cho, Teo, Cope, Gessler, Romer and Sukumar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HEYL functionally regulates angiogenesis in vitro and supports tumor growth in vivo. (A) Branched network formation on Matrigel of HUVEC cells incubated with complete EGM2 medium, or conditioned medium from HS578T-tet-off-HEYL-induced, or –uninduced cells. (B) The quantification of cells with more than 3 branching sites in (A). (C) Antibodies that neutralize CXCX1/2/3, or a CXCR2 inhibitor, SB265610 (SB) reduced HUVEC branched network formation. (D) The quantification of cells with more than 3 branching sites in (C). (E) Cell migration assay with HS578T-tet-off-HEYL cell- induced or uninduced conditioned media. Panels show stained HUVECs that have migrated through a membrane in a Boyden chamber assay. (F) Growth rate of xenografts in nu/nu mice of MDA-MB-231 with scr-shRNA (n=9) or shRNA1 (n=7) and shRNA2 (n=8) targeting HEYL. *P < 0.05; **< 0.05; ***< 0.001.