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. 2021 Jan 15;11:628101. doi: 10.3389/fphys.2020.628101

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Copyright © 2021 Reis Costa, Silveira, Campos, Nóbrega, de Araújo, de Figueiredo Borges, dos Santos Aggum Capettini, Ferreira and Bonaventura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vasodilator response induced by ACh in the presence or absence of PVAT in aortas of control and HC groups. Cumulative concentration-response curves for ACh in the presence or absence of PVAT in aortas of (A) control, (B) HC, and (C) overlapping curves of control and HC groups. Values represent mean ± SEM. The total number of animals required to carry out the experiments in each group (n) is presented in parentheses in the graphs. Statistical significance was determined using two-way ANOVA followed by Holm–Sidak’s post hoc test.