Skip to main content
. 2021 Jan 20;23(3):217. doi: 10.3892/mmr.2021.11856

Figure 4.

Figure 4.

Effects of β-Lapachone on the D1 receptor and ERK1/2 signaling in the L-DOPA-induced dyskinesia. Protein extracts from the striatum of the vehicle + L-DOPA and 10 mg/kg β-Lapachone + L-DOPA groups were subjected to western blot analysis using pGluR1, GluR1, pERK1/2, ERK1/2, ∆FosB and c-Fos antibodies (n=11 animals) and (A) representative blots are shown. (B) Semi-quantification of western blotting data. Values were normalized to actin values, and are presented relative to vehicle + L-DOPA in the unlesioned striatum. *P<0.05, **P<0.01 (n=11 animals; Student's t-test and one-way ANOVA). Data are presented as the mean ± SEM. 6-OHDA, 6-hydroxydopamine; β-LAP, β-Lapachone; L-DOPA, 3,4-dihydroxyphenyl-l-alanine; GluR1, AMPAR subunit glutamate receptor 1; pGluR1, phospho-GluR1 at Ser845; ERK1/2, extracellular signal regulated kinase 1/2; pERK1/2, phospho-ERK1/2 at Thr202/Tyr204; ∆FosB, deltaFosB; c-Fos, proto-oncogene c-fos.