Figure 5.

Effects of β-Lapachone on phosphorylation of GSK3-β in L-DOPA-induced dyskinesia. The protein extracts from the striatum of the vehicle + L-DOPA and 10 mg/kg β-Lapachone + L-DOPA groups were subjected to western blot analyses using p-Ser9-GSK3β and GSK3β antibodies (n=11 animals) and (A) representative blots are shown. (B) Semi-quantification of western blotting data. Values were normalized to actin, and are presented relative to vehicle + L-DOPA in the unlesioned striatum. **P<0.01 (Student's t-test and two-way ANOVA followed by Bonferroni post hoc test). Data are presented as the mean ± SEM. 6-OHDA, 6-hydroxydopamine; β-LAP, β-Lapachone; L-DOPA, 3,4-dihydroxyphenyl-l-alanine; p, phosphorylated.