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. 2021 Jan 19;23(3):213. doi: 10.3892/mmr.2021.11852

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Copyright: © Luo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effects of ROBO4 overexpression and ox-LDL treatment on VSMC viability, migration, invasion and apoptosis. (A) Transfection efficiency of ROBO4 overexpression. ROBO4 (B) mRNA and (C) protein expression levels in human VSMCs following ROBO4 overexpression and ox-LDL treatment. (D) Bcl-2 and MMP2 expression levels were measured by reverse transcription-quantitative PCR. Effect of ROBO4 overexpression and ox-LDL treatment on human VSMC (E) viability, (F) migration, invasion (magnification, ×200) and (G) apoptosis. *P<0.05, **P<0.01, ***P<0.001 vs. NC or control; ^#P<0.05, ^##P<0.01 vs. ox-LDL + NC. ROBO4, roundabout guidance receptor 4; ox-LDL, oxidized-low density lipoprotein; VSMC, vascular smooth muscle cell; MMP2, matrix metallopeptidase 2; NC, negative control; OD, optical density.