FIG 1.

Antibacterial activities of Rempex compounds and their dependence on permeation and efflux. (A) Structures and activities (MICs, µg/ml) of representative Rempex compounds discussed in the text. The complete list of Rempex compounds and their activities are shown in Table S1. (B) Relationship between antibacterial activities of Rempex compounds (IC₅₀) and the effect of the permeability barrier on these activities as expressed by the ratio PAO1/PΔ6-Pore (r = −0.16, P = 0.004). (C) Plot of levofloxacin potentiation of Rempex compounds (MPC₈) as a function of their antibacterial activities (IC₅₀) (r = 0.30, P = 0.01).