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Simulated effects of 10 µM ranolazine (blue) and 1.5 µM flecainide (green) in isolated endocardial heterozygous SCN5A V411M mutated (red) cells. Drug-free wild-type (black) is also included for comparison. Action potential time courses (A), INaL time course (B), depolarization phase of the AP (C) and INaf time course (D).
