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. 2020 Dec 17;11:580481. doi: 10.3389/fphar.2020.580481

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Copyright © 2020 Cano, Zorio, Mazzanti, Arnau, Trenor, Priori, Saiz and Romero

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulated effects of 10 µM ranolazine (blue) and 1.5 µM flecainide (green) on action potentials and pseudo-ECGs in the presence of SCN5A V411M heterozygous mutation (red) using a one-dimensional (1D) tissue model of a transmural wedge preparation. Drug-free wild type (black) was also included for comparison. Action potentials from endocardial (A), midmyocardial (B) and epicardial cells (C). Representation of the simulated transmural 1D tissue, and its corresponding pseudo-ECG (D) obtained with a virtual electrode 2 cm away from the last epicardial cell.