TABLE 4.

Transition rates of the optimized flecainide model.

Names	Equations
Transition rates
α11+ and α11n	α11
α12+ and α12n	α12
β11+ and β11n	β11
β12+ and β12n	β12
αx+	9.72e-5×αx
βx+	2.85e-8×βx
α13+	1.29e-3×α13
α2+	2.93e3×α2
β3+	8.23e-9×β3
α3+	3.43e-7×α3
α4+	3.24×α2
β4+	3.27e-1×α3
αxn	1.54e-1×αx
α13n	2.49×α13
α2n	4.03e1×α2
β3n	7.07×β3
α4n	1.12e-3×α2
β4n	4.30e-3×α3
Affinities
k_on = kc_on	drug_charged×diffusion
k_off = kc_off	2.15e1×(1e-6)×exp((−0.7×V×F)/(R×T))×diffusion
kb_on = kcb_on	k_on
kb_off = kcb_off	8.07e-1×(1e-6)×exp((−0.7×V×F)/(R×T))×diffusion
kn_on	drug_neutral×diffusion
kn_off	400×(1e-6)×diffusion
kni_on	kn_on
kni_off	5.4×(1e-6)×diffusion
knc_on	kn_on
knc_off	800×(1e-6)×diffusion
Diffusion	5500 M−1 m−1

The first column indicates transition rate names while the second column indicates their corresponding equations. The top section of the table defines drug transition rates, which are analogous to their respective wild type counterparts. The bottom section of the table defines drug-channel affinities. Nomenclature for transition rates and affinities: charged drug (+), neutral drug (n), closed states (c), inactivated states (i), bursting states (b), drug binding to the channel (on), drug unbinding from the channel (off).