TABLE 5.

Transition rates of the optimized ranolazine model.

Name	Values
Transition rates
α11+ and α11n	α11
α12+ and α12n	α12
β11+ and β11n	β11
β12+ and β12n	β12
αx+	1.10e4×αx
βx+	1.27e-1×βx
α13+	2.7e-2×α13
α2+	1.15e5e3×α2
β3+	7.36e-2×β3
α3+	2.17e-2×α3
αxn	1.41e1×αx
α13n	3.41e2×α13
α2n	2.77e2×α2
β3n	2.87e-3×β3
Affinities
k_on = kc_on	drug_charged×diffusion
k_off = kc_off	100.5×(1e-6)×exp((−0.7×V×F)/(R×T))×diffusion
kb_on = kcb_on	k_on
kb_off = kcb_off	1.5012×(1e-6)×exp((−0.7×V×F)/(R×T))×diffusion
kn_on	drug_neutral×diffusion
kn_off	400×(1e-6)×diffusion
kni_on	kn_on
kni_off	5.4×(1e-6)×diffusion
knc_on	kn_on
knc_off	800×(1e-6)×diffusion
Diffusion	5500 M−1 m−1

The first column indicates transition rate names while the second column indicates their corresponding equations. See caption of Table 3 for definitions of the abbreviations.