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. 2020 Dec 8;11:607605. doi: 10.3389/fphar.2020.607605

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Copyright © 2020 Li, Yang, Chen, Guo, Gao, Wang, Duan and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MOF inhibited the proliferation and colon formation ability of thyroid cancer cells. (A,B) Decreased MOF mRNA and protein expression in stable MOF-knockdown BHP-10-3 and TT2609 cells were detected and verified. (C,D) CCK8 assay of stable MOF-knockdown cell line showed decreased proliferation ability. (E,F) Colony formation assay of MOF-knockdown or control BHP-10-3 and TT2609 cells. (G,H) EdU staining assay of stable MOF-knockdown or control BHP-10-3 and TT2609 cells. (I,J) Cyclin D1, Cyclin D2, p21 and p16 mRNA and protein expression in stable MOF-knockdown BHP-10-3 and TT2609 cells were performed by Western blot and qRT-PCR. (K,L) Cell cycle was measured using PT staining assay by FCM. *p < 0.05, **p < 0.01, ***p < 0.001.