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. 2020 Dec 8;11:607605. doi: 10.3389/fphar.2020.607605

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Copyright © 2020 Li, Yang, Chen, Guo, Gao, Wang, Duan and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MOF bound to TNK2 promoter element to mediate PI3K/AKT pathway. (A) Western blot assay was performed to detect the protein expression of PI3K/AKT pathway in N-thy-ori, BHP-10-3, TT2609 cell lines. (B,C) TNK2 mRNA expression in stable MOF-knockdown BHP-10-3 and TT2609 cells were detected by qRT-PCR. (D,E) Western blot analysis of TNK2, AKT and p-AKT in stable MOF-knockdown BHP-10-3 and TT2609 cells. *p < 0.05, **p < 0.01, ***p < 0.001. PI3K/AKT pathway was inhibited with MG149 treatment in thyroid cancer cells.