Figure 1 -.

Therapeutic modulation of TLR2 can influence the downstream immune response and promote better host outcome during bacterial infection. TLR2-targeted inhibitors can serve to limit generation of excessive, tissue-damaging pro-inflammatory cytokines or evasion of the host immune system, while activation of TLR2 signaling can aid in the production of beneficial host immune responses generated by a wide variety of cell types. TLR2 agonists can also act as potent vaccine adjuvants due to their ability to induce many different T cell responses. MAMP = microbe-associated molecular pattern