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. Author manuscript; available in PMC: 2021 Nov 26.
Published in final edited form as: Chem Commun (Camb). 2020 Nov 26;56(94):14744–14756. doi: 10.1039/d0cc06796b

Figure 1.

Figure 1.

Example structures of small molecule:RNA complexes. RNA structures rendered in ICM and small molecules highlighted in purple. A) SMN-C5 bound to the RNA duplex of the 5’-end splice site of Survival Of Motor Neuron 2 (SMN2) exon 7 (PDB 6HMO, Ref. 132). B) Ribocil-C bound to the flavin mononucleotide (FMN) riboswitch (PDB 5C45, Ref. 55). C) DMA-135 bound to stem loop II of the internal ribosomal entry site (IRES) of enterovirus 71 (EV71) (PDB 6XB7, Ref. 91). D) Benzimidazole 2 bound to subdomain IIa of the hepatitis C virus (HCV) IRES (PDB 3TZR, Ref. 61).