Table 3. Adjusted binary logistic regression analyses showing the relationship between each additional life stress event during pregnancy by type of event and risk for infection-related hospitalisations during childhood (N = 2,141, age 0–16).
| All infection-related hospitalisations OR (95% CI)† | LRTI OR (95% CI)† | URTI OR (95% CI)† | GI OR (95% CI)† | Other OR (95% CI)† | |
|---|---|---|---|---|---|
| All offspring (n = 2141) | |||||
| Death of a friend/relative | 1.04 (0.81, 1.33) | 0.92 (0.61, 1.41) | 1.12 (0.85, 1.47) | 1.64 (1.11, 2.41) | 1.30 (0.90, 1.87) |
| Financial problems | 1.13 (0.95, 1.34) | 1.15 (0.87, 1.53) | 1.01 (0.83, 1.23) | 1.25 (0.92, 1.70) | 1.23 (0.94, 1.61) |
| Pregnancy problems | 1.25 (1.06, 1.49) | 1.17 (0.88, 1.55) | 1.20 (0.99, 1.46) | 1.21 (0.90, 1.63) | 1.41 (1.08, 1.83) |
| Relationship problems | 1.07 (0.85, 1.34) | 1.31 (0.93, 1.85) | 1.01 (0.78, 1.30) | 1.55 (1.08, 2.22) | 1.34 (0.97, 1.86) |
| Residential move | 0.89 (0.74, 1.08) | 0.89 (0.65, 1.22) | 0.84 (0.68, 1.05) | 1.16 (0.84, 1.62) | 1.08 (0.81, 1.44) |
| Problems with other children | 1.78 (1.35, 2.36) | 1.68 (1.13, 2.49) | 1.71 (1.28, 2.27) | 1.69 (1.11, 2.59) | 1.84 (1.24, 2.68) |
| Male offspring (n = 1121) | |||||
| Death of a friend/relative | 1.11 (0.79, 1.55) | 1.00 (0.58, 1.73) | 1.33 (0.92, 1.92) | 1.73 (1.04, 2.89) | 1.27 (0.77, 2.12) |
| Financial problems | 1.25 (0.98, 1.59) | 1.50 (1.01, 2.22) | 1.05 (0.80, 1.39) | 1.53 (1.00, 2.35) | 1.73 (1.16, 2.58) |
| Pregnancy problems | 1.50 (1.18, 1.91) | 1.43 (0.98, 2.11) | 1.47 (1.12, 1.92) | 1.32 (0.87, 2.00) | 1.55 (1.06, 2.28) |
| Relationship problems | 1.32 (0.97, 1.81) | 1.38 (0.86, 2.20) | 1.24 (0.88, 1.75) | 1.46 (0.89, 2.40) | 2.02 (1.30, 3.15) |
| Residential move | 1.04 (0.80, 1.35) | 1.17 (0.77, 1.79) | 0.88 (0.64, 1.19) | 1.27 (0.81, 2.00) | 1.42 (0.94, 2.14) |
| Problems with other children | 2.21 (1.49, 3.26) | 2.51 (1.52, 4.16) | 1.93 (1.30, 2.86) | 1.94 (1.09, 3.44) | 2.76 (1.66, 4.59) |
| Female offspring (n = 1020) | |||||
| Death of a friend/relative | 0.97 (0.67, 1.41) | 0.82 (0.42, 1.58) | 0.92 (0.61, 1.40) | 1.48 (0.82, 2.66) | 1.31 (0.78, 2.21) |
| Financial problems | 1.01 (0.79, 1.30) | 0.85 (0.56, 1.29) | 0.97 (0.73, 1.28) | 0.99 (0.63, 1.56) | 0.88 (0.60, 1.28) |
| Pregnancy problems | 1.02 (0.80, 1.31) | 0.93 (0.61, 1.41) | 0.97 (0.74, 1.28) | 1.08 (0.70, 1.66) | 1.26 (0.88, 1.82) |
| Relationship problems | 0.84 (0.61, 1.17) | 1.23 (0.73, 2.04) | 0.81 (0.56, 1.18) | 1.63 (0.97, 2.75) | 0.84 (0.51, 1.38) |
| Residential move | 0.75 (0.57, 0.99) | 0.63 (0.39, 1.01) | 0.80 (0.59, 1.09) | 1.02 (0.62, 1.65) | 0.81 (0.53, 1.22) |
| Problems with other children | 1.42 (0.94, 2.12) | 0.96 (0.49, 1.87) | 1.51 (0.99, 2.30) | 1.45 (0.77, 2.74) | 1.20 (0.69, 2.11) |
†odds ratio and 95% confidence intervals, each line reflects a separate logistic regression model. Model adjusted for maternal age at pregnancy, maternal education at pregnancy and maternal smoking in pregnancy. LRTI: Lower respiratory tract infection; URTI: Upper respiratory tract infection; GI: Gastrointestinal infection; Other: Genitourinary infection, skin and soft tissue infection or other viral infection.