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(A-I) Representative PI(3,5)P2 (1 μM) activated current densities in vacuolin-enlarged lysosomal vesicles isolated from HEK293 cells overexpressing different human TPC2 variants and the corresponding currents after block with ATP (1 mM). (J) Statistical summary of data as shown in A-I and in Fig 4A and 4B. Shown are average current densities (mean ± SEM) at -100 mV. Unpaired t-test were applied. *p < 0.05 and **p < 0.01.
