Fig 1. Intrinsic and soft structural disorder.

We show a sketch of the differences between A the traditional intrinsic disorder (defined through the missing residues of the X-crystallographic structure) and B, our definition of soft disorder extracted from the high B-factor regions. As more alternative structures of a given protein are included in the analysis, see C, the number of always missing residues decreases and a large part of them get eventually structured (the so-called disorder-to-order (DtO) residues). The soft disordered parts grows with the number of structures considered too, see D. We observe that the DtO regions are generally characterised also as soft disordered, while missing residues cannot be by definition. The chart sizes are arbitrary, we discuss the relative size and the intersection between both definitions of structural disorder in Fig 6.