Table 2.
Comparisons of the test-compound mutagenicity observed herein with previously published results for other in vitro mammalian cell mutagenicity assays
| Compound | lacZ | Tk | Hprt | ||
|---|---|---|---|---|---|
| MutaMouse FE1 cells | Mouse lymphoma L5178Y cells | Human TK6 cells | Chinese hamster V79 cells | Chinese hamster ovary cells | |
| Acrylamide −S9 | Equivocal | Positivea (25) | Positivea (26) | Negative (27) | No data |
| Acrylamide +S9 | Positive | No data | Positivea (26) | No data | No data |
| Glycidamide −S9 | Positive | Positive (25) | Positive (26) | Positive (27) | No data |
| PhIP −S9 | Negative | No data | No data | Negative (36) | No data |
| PhIP +S9 | Positive | No data | Positive (37) | Positiveb (36) | No data |
| N-OH-PhIP −S9 | Positive | No data | No data | No data | No data |
| 4-ABP −S9 | Negative | No data | No data | No data | No data |
| 4-ABP +S9 | Negative | Equivocalc (38) | No data | No data | Positive (39) |
| N-OH-4-ABP −S9 | Negative | No data | No data | No data | No data |
aOnly weakly genotoxic at concentrations above 10 mM.
bCells expressed human CYP1A2.
cOnly positive at one criteria; large variability.