Figure 2.

Relative potency of perfluoroalkyl acids and FTOHs based on reactivity with various human nuclear receptors, using PFOA as the index chemical. See Supplementary Table 2 for corresponding tabular summary of binding activity metrics and values. PPAR-α, C_20max, human peroxisome proliferator-activated receptor alpha, concentration that produces 20% of the maximal response; PPAR-alpha, AC₅₀, human peroxisome proliferator-activated receptor alpha, half-maximal activity concentration; FABP, human liver fatty acid binding protein; PXR, human pregnane X receptor; TR, human thyroid receptor.