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. 2020 Apr 6;46(6):1547–1557. doi: 10.1093/schbul/sbaa038

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.All rights reserved. For permissions, please email: journals.permissions@oup.com

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Fig. 4. — Molecular model of CB₁R-5-HT_2AR-HET. (A) Detailed view of 5-HT_2AR bound to CLZ (fuscia), OLZ (light blue), HAL (yellow), or ARP (red), showing that the aromatic ring of CLZ/OLZ, in contrast to the others, expands towards TM6 and interacts with F6.52. (B) Quaternary structure of the CB₁R-5-HT_2AR-HET to illustrate how CLZ/OLZ and THC interact with amino acids near the heteromerization interface (TMs 5&6) that could trigger changes in the interface. (C) Binding of THC (orange) to CB₁R shows that the alkyl chain interacts with L5.42, W5.45, and M6.55 in TMs 5&6.