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. 2021 Jan 19;15(1):e0009006. doi: 10.1371/journal.pntd.0009006

Table 3. Time trends of VL epidemiologic indicators.

Indicator/variable Segmented period Entire period
Period APC (95%CI) Trend AAPC (95%CI) Trend
Crude prevalence rate (per 100,000 inhab.)
2000–2017 -1.4 (-2.6 to 0.2) Decreasing
Crude incidence rate (per 100,000 inhab.)
General 2000–2017 -1.22 (-2.5 to 0.1) Stable
Federative Unit/State
Alagoas 2000–2007 -26.2 (-33.5 to -18.1) Decreasing -10.6 (-16.3 to -4.6) Decreasing
2007–2017 2.2 (-7.5 to 12.9) Stable
Bahia 2000–2017 -1.1 (-3.6 to 1.4) Stable
Ceará 2000–2006 24.8 (8.5 to 43.6) Increasing 5.5 (0.2 to 10.9) Increasing
2006–2017 -3.8 (-7.6 to 0.2) Stable
Maranhão 2000–2009 -8.2 (-13.1 to -3.0) Decreasing -1.8 (-5.5 to 2.1) Stable
2009–2017 6.0 (-0.8 to 13.3) Stable
Paraíba 2000–2017 -2.2 (-6.2 to 2.0) Stable
Pernambuco 2000–2003 -43.7 (-60.9 to -18.7) Decreasing -6.2 (-12.3 to 0.2) Stable
2003–2017 4.6 (0.3 to 9.1) Increasing
Piauí 2000–2004 28.5 (5.8 to 56.0) Increasing 3.4 (-3.2 to 10.4) Stable
2004–2009 -13.2 (-26.9 to 3.1) Stable
2009–2017 3.4 (-3.3 to 10.5) Stable
Rio Grande do Norte 2000–2003 -42.8 (-50.8 to -33.4) Decreasing -7.8 (-11.3 to -4.2) Decreasing
2003–2011 7.4 (1.5 to 13.5) Increasing
2011–2017 -4.5 (-10.2 to 1.6) Stable
Sergipe 2000–2002 -31.6 (-68.6 to 48.9) Stable -1.7 (-9.9 to 7.4) Stable
2002–2017 3.2 (-0.4 to 7.0) Stable
Sex
Male 2000–2017 1.4 (0.8 to 2.0) Increasing
Female 2000–2017 -2.6 (-3.9 to -1.3) Decreasing
Age
≤ 4 years 2000–2017 -1.4 (-3.0 to 0.3) Stable
5–19 years 2000–2002 -23.1 (-41.6 to 1.3) Stable -3.6 (-6.6 to -0.5) Decreasing
2002–2017 -0.7 (-2.2 to 0.8) Stable
20–39 years 2000–2017 0.6 (-0.6 to 1.8) Stable
40–59 years 2000–2017 3.8 (2.2 to 5.4) Increasing
≥ 60 years 2000–2017 5.9 (4.2 to 7.6) Increasing
Percentage of LV-HIV co-infection
2000–2011 24.98 (15.8 to 34.9) Increasing 17.3 (11.3 to 23.7) Increasing
2011–2017 4.5 (-4.2 to 13.9) Stable
Crude mortality rate (per 100,000 inhab.)
2000–2009 -0.9 (-3.8 to 2.0) Stable 2.5 (0.6 to 4.4) Increasing
2009–2017 6.5 (3.4 to 9.7) Increasing
Lethality
2000–2017 3.9 (3.0 to 4.9) Increasing
Proportion of municipalities with transmission
2000–2010 -0.8 (-2.4 to 0.8) Stable 1 (-0.3 to 2.3) Stable
2010–2017 3.6 (1.0 to 6.4) Increasing