Table 4.

Effect of E-Cigarette Liquids and Nicotine on Micronuclei Formation in Oral Epithelial Cell Lines

E-Liquid a	Cell Lines
	MOE1A		MOE1B		MSK1
	(–)	(+)	(–)	(+)	(–)	(+)
			(Maximum Significant Fold Change)
Unflavored	1.3*	NS	NS	NS	1.3*	1.8
Arctic Blast	NS	NS	NS	NS	NS	NS
Blue Pucker	1.7	1.5	1.4	1.5	2.0	1.6
Jamestown	NS	1.4*	2.8*	2.1*	NS	1.5*
Love Potion	1.4	NS	NS	NS	NS	NS
Mardi Gras	2.5	1.4	NS	1.7	NS	NS
Midnight Splash	NS	2.0	NS	NS	NS	5.4
Port Royale	NS	NS	NS	1.3*	NS	1.5
Tobacco Row	NS	NS	1.7	NS	2.5	4.7*
Tortuga	1.6*	NS	NS	NS	NS	NS
Uptown	NS	2.0	2.4*	NS	2.2	NS
Kentucky Reference Cigarette 3R4F	1.8		2.8		4.0*

Abbreviations: (–), no nicotine; (+), nicotine; NS, not significant.

^aAll e-liquids contain 70%PG/30%VG.

^* p < .05 for dose response trend test.