Table 4.
Canonical pathways identified by IPA using a list of DEGs for liver abscesses
| Canonical pathway | P-value | No. of genes | Gene names1 |
|---|---|---|---|
| EIF2 signaling | 0.0003 | 8 | EIF3A, IGF1R, RPL22, RPL38, RPL39, RPL36AL, RPS25, RPS27L |
| Interferon signaling | 0.003 | 3 | IFI6, RELA, TYK2 |
| iNOS signaling | 0.005 | 3 | LY96, RELA, TYK2 |
| Hepatic fibrosis/ hepatic stellate cell activation | 0.01 | 5 | COL7A1, IGF2, IGF1R, LY96, RELA |
| Role of JAK1, JAK2 and TYK2 in interferon signaling | 0.01 | 2 | RELA, TYK2 |
1 EIF3A, eukaryotic translation initiation factor 3 subunit A; IGF1R, insulin-like growth factor 1 receptor; RPL22, ribosomal protein L22; RPL38, ribosomal protein L38; RPL39, ribosomal protein L39; RPL36AL, ribosomal protein L36a Like; RPS25, ribosomal protein S25; RPS27L, ribosomal protein S27 like; IFI6, interferon alpha inducible protein 6; RELA, RELA proto-oncogene, NFKB subunit; TYK2, tyrosine kinase 2; COX7A1, cytochrome C oxidase subunit 7A1; IGF2, insulin-like growth factor 2; LY96, lymphocyte antigen 96.