Table 1.
Patients’ clinical characteristics, treatments, and outcome
| Group A | Group B | P-value | |
|---|---|---|---|
| n = 54 (%) | n = 38 (%) | ||
| Boys/girls | 36 /18 (66.7 / 33.3) | 24/14 (63.2 / 36.8) | 0.7279 |
| Median age, y (range) | 4.7 (0.8–18.0) | 5.4 (0.1–13.9) | |
| Age class at diagnosis | 0.3970 | ||
| ≤5 y | 29 (53.7) | 17 (44.7) | |
| >5 y | 25 (46.3) | 21 (55.3) | |
| Histological diagnosis of medulloblastoma | 0.0542 | ||
| Classic | 35 (64.8) | 33 (86.8) | |
| Nodular/desmoplastic | 10 (18.5) | 2 (5.3) | |
| Anaplastic/large cell | 7 (13.0) | 1 (2.6) | |
| Other or NOS | 2 (3.7) | 2 (5.3) | |
| Hydrocephalus (yes/no) | 31/23 (57.4 / 42.6) | 33/5 (86.8 / 13.2) | 0.0025 |
| Place of the surgery (Necker/ other centers) | 30/24 (56 / 44) | 34 / 4 (89 / 11) | 0.0005 |
| Median initial tumor size at the primary site, cm2 (range) | 12.66 (3.20–22.14) | 12.56 (2.42–31.30) | 0.8726 |
| Treatment regimen combined with surgery* | 0.2990 | ||
| CC + RT | 2 (3.7) | 1 (2.6) | |
| CC + HDC + standard RT | 22 (40.7) | 23 (60.5) | |
| CC + HDC + decreased RT CC + HDC without RT | 28 (51.9) 2 (3.7) | 13 (34.2) 1 (2.6) | |
| Outcome (dead/alive) | 25/29 (46.3 / 53.7) | 16/22 (42.1 / 57.9) | 0.6905 |
Abbreviations: NOS not otherwise specified, CC conventional chemotherapy, RT radiotherapy, HDC high-dose chemotherapy.
* Intent to treat.