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Comparisons for the ligation of 3’-8-oxodG:A substrate by the wild-type and LIG1 variants. (A, B) The graphs show the time-dependent changes in the ligation (A) and ligation failure (B) products for the wild-type and LIG1 variants P529L, R641L and R771W. The data are presented as the averages from three independent experiments ± SDs.
