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. 2020 Sep 11;35(5):391–404. doi: 10.1093/mutage/geaa023

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Figure 6. — Architecture of LIG1 showing the positions of the disease-associated residues in complex with the nicked DNA containing 8-oxoG:A. (A) Ribbon diagram shows LIG1 (grey) encircling the nicked DNA (sticks) with 8-oxoG opposite template A (green). E566, R641 and R771 (magenta) are represented by sticks. (B) Nucleotide-residue contact map showing individual LIG1 residues interactions that are close proximity to R641 (loop A, green) and R771 (loop B, red) with the nicked DNA containing 8-oxoG:A.