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Supposed signaling pathways initiated by SARS-CoV-2. Illustration representing main signaling pathways hypothesized to be triggered by SARS-CoV-2 leading to cytokine storm in complicated cases. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; IκB, inhibitor of nuclear factor kappa B; NF-κB, nuclear factor kappa B; TNF- α; tumor necrosis factor alpha, IL-6, interleukin 6; JAK/STAT, Janus kinase/ signal transducer and activator of transcription [8].
