Figure 5.

The chemokine expression profile of the upper and lower respiratory tract in infected golden hamsters

(A and B) Differential gene expression of a curated list of chemokines and cytokines calculated from bulk mRNA-seq from (A) the trachea and (B) the lungs of hamsters infected with SARS-CoV-2 for the times and dosages indicated compared with uninfected controls. The heatmaps represent the log2 fold change of each gene indicated on the right (human ortholog) at the time points below (control group, n = 5; each experimental group, n = 3).

(C and D) Mean number of rpm from RNA-seq mapping to (C) Ifnb or (D) Ifnl in the trachea 1 day after infection (n = 3).

(E) Mean IgG antibody titers specific to the spike protein in 9- to 10-week-old hamsters and controls (n = 8) 7 (n = 11), 14 (n = 11), and 21 (n = 6) days after infection, measured by ELISA and depicted as area under the curve (AUC).

Error bars indicate standard deviation. See also Figure S5.